FABER, the screening test for IgE-mediated allergies:
a precise, comprehensive, unique, and powerful tool

FABER Nano-technology

The patent pending technology which the FABER test is based on was developed by MacroarrayDx. Hundreds of molecular allergens or allergen extracts are coupled to chemically activated nanoparticles. These particles are then arrayed to a solid phase matrix, to form a one-step comprehensive array based testing solution, using only minimal amounts of patient sample (100 microliter per test). Using this technology, each allergen particle population can be individually optimized to achieve the maximum testing performance, and there is no trade-off between number of tests and performance.

FABER allergen preparations: Molecules and Extracts

Allergenic molecules and allergen extracts are obtained only from the highest quality providers in the field. Each allergenic preparation is checked for purity and allergenic activity by several methods before including it into the test panels. Each allergen preparation was selected based on clinical relevance, carefully evaluated and compared to reference methods.

The inclusion of allergenic extracts in the FABER test aims to confirm or complement the results obtained with the single allergenic molecules where currently not all allergenic molecules are already available.

When is it worth doing the FABER test?

• In case of allergy with rhinitis, conjunctivitis, asthma, urticaria, eczema, food reactions including abdominal pain and diarrhea, or insect or latex-induced reactions.


• When more than one symptom appear all together and are caused by several triggers.


• In case of restriction diets without success, and trying to avoid allergen exposure without improving your condition.


• If there are other members of a family being allergic.


• To know whether about allergy before traveling, starting a new job, or a new activity for leisure.


• In case of high total IgE or eosinophils values.


• To go for an allergy vaccine.


• To perform a periodical screening test for early diagnosis.

Where can I get the FABER test?

The FABER test is currently exclusively available from our partner lab, Sermolab S.r.l. Blood drawing can be done in any of the CAAM network centers or by sending the sample directly to Sermolab S.r.l.

Please enquire for instructions by sending an email to faber@caam-allergy.com.

FABER test management and reporting

• The FABER test software allows to control all testing steps.


• InterAll receives data from the lab software and allows to produce electronic (pdf) or paper reports. InterAll helps specialists to dynamically visualize the FABER test results.


• Using the CDRS the patient may visualize performed test results in a dynamic way as allowed by the linked databases.

Who is the FABER test maker?

The IBBR-CNR evaluates and makes allergenic preparations available, doing all the required biochemical procedures to verify allergen quality.

The ADL team develops and maintains the Allergome platform, and the external modules, InterAll, ReTiME, and the new CDRS.

CAAM molecular allergologists and the CAAM lab team at the Sermolab are responsible for performing the lab testing and test result evaluation as well as clinical evaluation of the test results.

MacroarrayDx is a Vienna based company founded by the original inventors of ISAC technology, who have now developed the next generation in vitro testing and software tools for immunodiagnostic applications.

Other FABER partners

Italy:

France:

Poland:

Lebanon:

Spain:

Mexico:

Greece and Cyprus:

Romania:

Hungary:

Philippines:

Hong Kong and Macao:

Chile, Panama, Paraguay and Peru:

Turkey:

Nigeria:

Paraguay:

Current test version: FABER 244-122-122 06

The currently used version of the FABER test is identified using an univocal encoding with 4 numbers:

• 1) Total number of tests (allergenic preparations)
• 2) Number of allergenic molecules
• 3) Number of allergenic extracts
• 4) Variant

The identification of the FABER test version is displayed in paper and electronic pdf reports and in the CDRS.

For the full list of allergenic preparations present in the FABER test click here to download the demo version of the lab report. For all other in language version of the report click here.

For a dynamic and advanced visualization of the FABER test please use the demo version of the CDRS. The CDRS allows to shift from one to another of the available twelve different languages.

The FABER test is in conformity with CE marking complying with the European Directive 98/79/CE.

The FABER test is classified as IVD and assigned the unique code RDM: 1498039, categories CND: W01020204 and EMDA: 12020105 repositories.

FABER test cost

The FABER 244 test cost is identical to the previous ISAC 112 one, but the cost per single tested allergen preparation (molecule or extract) decreased at least 2 fold.

The comprehensiveness of the FABER test and the preliminary interpretation of the test by means of the CDRS allows to make a good saving on direct and indirect costs generated by the "classic" in vivo allergy diagnosis (skin test) and by the lab diagnosis using single-plex methods, where with the same overall cost only 10 tests using molecules or 20 tests using extracts might be performed.

Financial support to the FABER test

ADL Srl has received funding for the FABER test development project from the European Union's Horizon 2020 research and innovation programme under grant agreement No 866356 – FABER-Net.

Scientific publications

• 2017

2017

1. Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Tuppo L, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA.
   Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures.
   Clin Transl Allergy 2017;7:21.
2. Tuppo L, Alessandri C, Pasquariello MS, Petriccione M, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA.
   Pomegranate cultivars: identification of the new IgE-binding protein pommaclein and analysis of anti-oxidants variability.
   J Agric Food Chem 2017;65:2702-10.

Scientific communications

• 2018
• 2017
• 2016

2018

1. Monsálvez MP, Lara MF, Cereceda DA, Berho JM, Grau M, Córdova A, Mardones P.
   Anafilaxia con homólogos de Bet v 1, posterior a una cirugía bariatrica. Reporte de un caso.
   XXVIII Congreso Internacional de la Sociedad Chilena de Alergia e Inmunologia - Vitacura - Santiago, Chile, 2018
2. Nicaise-Roland P, Garnier L, Klingebiel C, Chabane H, Vitte J, Apoil PA
   A comparative study of two multiplex platforms for molecular-based allergy diagnostics.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.
3. Sobarzo MA
   Sensitization to lipid transfer proteins and profilins in patients treated at the clinical hospital of The University of Chile between March and August of 2013.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.
4. Tuppo L, Alessandri C, Tamburrini M, Giangrieco I, Ricciardi T, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA.
   Identification of 2S albumin from pomegranate seeds as an IgE-binding protein.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.
5. Alessandri C, Guggiari Doutreleau J, Mardones P, Pietrosanti I, Ciancamerla M, Rafaiani C, Ciardiello MA, Mari A.
   A standard diagnostic tool to explore allergic sensitization across distant countries in two continents.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.
6. Alessandri C, Giangrieco I, Tuppo L, Samolinski B, Emeryk A, Nicolae CA, Miškovic S, Bosotina M, Wu A, Zennaro D, Rafaiani C, Ferrara R, Bernardi ML, Ciancamerla M, Tamburrini M, Majsiak E, Ciardiello MA, Mari A.
   Different sensitization profiles to Mammalian Serum Albumins as detected by a New IgE Detection Multiplex Assay.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.
7. Alessandri C, Ferrara R, Zennaro D, Wu A, Nicolae CA, Miškovic S, Bosotina M, Samolinski B, Emeryk A, Tuppo L, Giangrieco I, Rafaiani C, Ciancamerla M, Bernardi ML, Majsiak E, Tamburrini M, Ciardiello MA, Mari A.
   IgE Sensitization to Inhalable and Ingestable Fungi by means of a New Allergy Test in Three different Continents: A Preliminary Report.
   Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Munich, Germany, 2018.

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2017

8. Mari A, Alessandri C, Zennaro D, Ferrara R, Bernardi ML, Tuppo L, Giangrieco I, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA.
   The Most Comprehensive Allergen Panel to Diagnose Peanut Sensitization using a New Multiplex Nanobead-Based Biochip.
   7th International Symposium on Molecular Allergology - Luxembourg, 2017.
9. Mari A, Rafaiani C, Ciancamerla M, Alessandri C, Zennaro D, Ferrara R, Bernardi ML, Tuppo L, Giangrieco I, Tamburrini M, Ciardiello MA.
   A New Multiplex IgE Diagnostic Test based on Nanobeads: Allergen IgE Binding, Reproducibility and Comparative Performances toward Three Different Singleplex Testing Systems.
   7th International Symposium on Molecular Allergology - Luxembourg, 2017.
10. Alessandri C, Tuppo L, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Ciardiello MC, Mari A.
    Class III chitinase is an additional IgE binding protein identified in pomegranate.
    7th International Symposium on Molecular Allergology - Luxembourg, 2017.
11. Alessandri C, Nicolae CA, Miškovic S, Samolinski B, Buczylko K, Wu A, Shokouhi Shoormatsi R, Ferrara R, Zennaro D, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Giangrieco I, Tuppo L, Berghea EC, Pourpak Z, Majsiak E, Ciardiello MC, Mari A.
    Exploring the Allergic Sensitization Prevalence Across Different Countries Worldwide by means of a New Multiplex Diagnostic Tool.
    7th International Symposium on Molecular Allergology - Luxembourg, 2017.
12. Mari A, Alessandri C, Zennaro D, Ferrara R, Bernardi ML, Tuppo L, Giangrieco I, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA.
    FABER 244 Multiplex IgE Diagnostic Test, a new nanobead-based tool for Allergy Diagnosis: Reporting on IgE reactivity of single allergen preparations, result reproducibility and comparative performances with three singleplex testing systems.
    12. Deutscher Allergie Kongress - DGAKI - Wiesbaden, Germany, 2017.
13. Mari A, Alessandri C, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MC.
    FABER IgE diagnostic test: the broad view on IgE reactivity to seeds, legumes, nuts, and cereals.
    12. Deutscher Allergie Kongress - DGAKI - Wiesbaden, Germany, 2017.
14. Vitte J, Klingebiel C, Poisson A, Porri F, Liabeuf V, Cleach I, Mège J-L.
    Multiplex method for IgE determination: a report of six severe peach allergic patients from Southern France.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
15. Nicaise-Roland P, Garnier L, Epstein M, Villard-Truc F, Gomez S-A, Silcret-Grieu S, Bienvenu F, Chollet-Martin S, Chabane H.
    Evaluation of a multiplexed biochip (friendly allergen nano-bead array) in different clinical contexts.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
16. Mari A, Mitterer A, Rafaiani C, Ciancamerla M, Alessandri C, Bernardi ML, Tuppo L, Giangrieco I, Ferrara R, Zennaro D, Tamburrini M, Ciardiello MA, Harwanegg C.
    Introducing the FABER 244 Multiplex IgE diagnostic test, A new Nanobead-based tool for Allergy Diagnosis: Reporting on IgE Reactivity of Single Allergen Preparations and Reproducibility Performances.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
17. Rossi R, Minelli M, Ferrara R, Zennaro D, Bernardi ML, Vergallo I, Maio D, Rafaiani C, Ciancamerla M, Tamburrini M, Tuppo L, Giangrieco I, Ciardiello MA, Mari A, Alessandri C.
    FABER IgE Test: a Standard Multiplex Diagnostic Tool to Explore Allergic Sensitization across Northern, Central and Southern areas in Italy.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
18. Alessandri C, Giangrieco I, Tuppo L, Ferrara R, Zennaro D, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: the Most Comprehensive View on IgE Sensitization to Vegetables, Fruits and Seeds due to Lipid Transfer Proteins.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
19. Alessandri C, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: the Broad View on IgE Reactivity to Seeds, Legumes, Nuts, and Cereals.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
20. Alessandri C, Zennaro D, Rafaiani C, Ferrara R, Bernardi ML, Ciancamerla M, Tuppo L, Giangrieco I, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: IgE Sensitization to Furry Animal Dissected by Allergenic Molecules and Extracts.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
21. Alessandri C, Tuppo L , Giangrieco I, Ferrara R, Bernardi ML, Zennaro D, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: House Dust Mite Sensitization Dissected using Six Allergenic Molecule Groups.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
22. Alessandri C, Tuppo L , Giangrieco I, Ferrara R, Bernardi ML, Zennaro D, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: a Useful help in Understanding IgE Sensitization to Fishes.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
23. Alessandri C, Giangrieco I, Tuppo L, Bernardi ML, Zennaro D, Ferrara R, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE diagnostic test: Exploring IgE Sensitization to Tropomyosins and related Sea Foods and Arthropods.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
24. Mari A, Mitterer G, Rafaiani C, Ciancamerla M, Alessandri C, Bernardi ML, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Tamburrini M, Ciardiello MA, Harwanegg C.
    FABER 244 multiplex IgE diagnostic test performaces compared to singleplex Phadia ImmunoCAP, Siemens Immulite 2000, and Hycor Hytec 288 testing systems.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
25. Shokouhi Shoormasti R, Rafaiani C, Alessandri C, Ciancamerla M, Moin M, Fazlollahi MR, Mahloogirad M, Abbasi JM, Ciardiello MA, Pourpak Z, Mari A.
    Comparing IgE reactivity distribution between Iranian and Italian allergic patients using the FABER IgE diagnostic test.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
26. Mari A, Carabella G, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Nuti S, Monti S, Alessandri C.
    CDRS and CDRS PRO: the CAAM Digital Reporting System an Exclusive Online Free tool for Allergy test Visualization dedicated to Patients and Accessible by Allergists.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
27. Alessandri C, Tuppo L, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA.
    Identification of the IgE-binding protein Pommaclein, Pun g 7, in Pomegranate Fruit.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
28. Tuppo L, Alessandri C, Pasquariello S, Petriccione M, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA.
    Variability of the allergen pattern in different pomegranate cultivars.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
29. Mišković S, Nicolae CA, Grgic P, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Giangrieco I, Tuppo L, Ciardiello MA, Mari A, Alessandri C.
    FABER IgE Test: a Standard Multiplex Diagnostic Tool to Explore Allergic Sensitization across different European regions: Romania, Croatia, Italy.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
30. Alessandri C, Tuppo L, Zennaro D, Rafaiani C, Ciancamerla M, Giangrieco I, Ferrara R, Bernardi ML, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE Diagnostic Test: the Most Comprehensive view on IgE Sensitization to Milks and Meats.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
31. Alessandri C, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Tamburrini M, Ciardiello MA, Mari A.
    FABER IgE diagnostic test: the most comprehensive view on IgE sensitization to egg and poultry allergens.
    Annual Congress of the European Academy of Allergy and Clinical Immunology - EAACI - Helsinki, Finland, 2017.
32. Rossi R, Alessandri C, Zennaro D, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Mari A.
    Sensibilizzazione allergica in gruppi di pazienti abitanti in due differenti regioni italiane. Analisi preliminare dei dati raccolti mediante test multiplexing FABER 244 per il dosaggio delle IgE specifiche.
    XXX Congresso Nazionale Società Italiana di Allergologia, Asma ed Immunologia Clinica. SIAAIC 2017. Firenze, Italy, 2017.
33. Tuppo L, Alessandri C, Pasquariello S, Petriccione M, Giangrieco I, Tamburrini M, Rafaiani C, Ciancamerla M, Mari A, Ciardiello MA.
    Il dosaggio delle IgE specifiche con il test FABER nello studio della sensibilizzazione alle Lipid Transfer Proteins.
    XXX Congresso Nazionale Società Italiana di Allergologia, Asma ed Immunologia Clinica. SIAAIC 2017. Firenze, Italy, 2017.
34. Mari A, Mitterer G, Rafaiani C, Ciancamerla M, Alessandri C, Bernardi ML, Giangrieco I, Tuppo L, Zennaro D, Ferrara R, Tamburrini M, Ciardiello MA, Harwanegg C.
    Valutazione comparativa del test diagnostico multiplex IgE FABER 244 verso i sistemi singleplex Phadia ImmunoCAP, Siemens Immulite 2000, e Hycor Hytec 288.
    XXX Congresso Nazionale Società Italiana di Allergologia, Asma ed Immunologia Clinica. SIAAIC 2017. Firenze, Italy, 2017.
35. Mari A, Carabella G, Zennaro G, Ferrara R, Bernardi ML, Rafaiani C, Ciancamerla M, Nuti S, Monti S, Alessandri C.
    Il CAAM Digital Reporting System (CDRS & CDRS PRO): un sistema free online ed esclusivo per la visualizzazione dei test per l’allergia, dedicato ai pazienti e accessibile agli allergologi.
    XXX Congresso Nazionale Società Italiana di Allergologia, Asma ed Immunologia Clinica. SIAAIC 2017. Firenze, Italy, 2017.
36. Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Rafaiani C, Ciancamerla M, Tuppo L, Giangrieco I, Tamburrini M, Ciardiello MA, Mari A.
    Determinazione delle IgE specifiche con il test FABER nello studio della sensibilizzazione agli acari della polvere.
    XXX Congresso Nazionale Società Italiana di Allergologia, Asma ed Immunologia Clinica. SIAAIC 2017. Firenze, Italy, 2017.

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2016

37. Mari A, Alessandri C, Giangrieco I, Tuppo L, Rafaiani C, Mitterer G, Ciancamerla M, Ferrara R, Bernardi ML, Zennaro D, Tamburrini M, Ciardiello MA, Harwanegg C.
    Introducing FABER Test for Allergy Diagnosis: food molecule- and extract-based allergenic preparations in the newest and broadest nanotechnology IgE test.
    EAACI Food Allergy and Anaphylaxis Meeting – FAAM. Rome, Italy, 2016.
38. Alessandri C, Ciardiello MA, Tuppo L, Giangrieco I, Zennaro D, Ferrara R, Bernardi ML, Mitterer G, Rafaiani C, Ciancamerla M, Tamburrini M, Harwanegg C, Mari A.
    FABER 244 IgE Test in Food Allergy. Diagnostic accuracy for LTP proteins.
    EAACI Food Allergy and Anaphylaxis Meeting – FAAM. Rome, Italy, 2016.

Scientific reports

• 2018
• 2017
• 2016

2018

1. X Konferencja Szkoleniowa Polskie Towarzystwo Alergologiczne - Dobra diagnoza – dobre leczenie - “Diagnostyka molekularna – korzyści dla lekarza prowadzącego i pacjenta “. Wisła, Poland, 2018. Mari A.
2. Formazione Avanzata Teorica e Applicata - “Profiling Personalizzato del Paziente con Sensibilizzazione IgE-specifica: La Diagnostica Allergologica del Terzo Millennio “. Udine, Italy, 2018. Mari A.
3. Ospeday - “La Diagnostica Allergologica Moderna: il FABER test “. Potenza, Italy, 2018. Mari A.

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2017

4. World Allergen & Smart Food Expo - “Diagnosi Personalizzata di Allergia nell’Era della Medicina di Precisione e dell’Information Technology “. Padova, Italy, 2017. Mari A.
5. Simpozion de Alergii Medicamentoase - “Test FABER pentru Alergii IgE-mediate: Nu doar cel mai Avansat Test de Alergie bazat pe Nanotehnologie “. Bucuresti, Romania, 2017. Mari A.
6. Percorsi Avanzati in Allergologia – IX Edizione - “La Diagnostica Molecolare Applicata alla Clinica Allergologica: Confronti Tecnici”. Pozzuoli (Na), Italy, 2017. Mari A.
7. 1° Convegno della Sezione meridionale della Società Italiana di Medicina Personalizzata - “Profiling personalizzato del paziente con allergie IgE-mediate: la diagnostica allergologica del terzo millennio “. Lecce, Italy, 2017. Mari A.
8. Department of Biotechnology, University of Verona – Seminar “3 Technologies for Third Millennium Allergy Diagnosis” Verona, Italy, 2017. Mari A.

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2016

9. Ordine Nazionale dei Biologi - Webinar - “La Diagnostica Allergologica del Terzo Millennio: Molecole Allergeniche, Nanotech & ICT”. Rome, Italy, 2016. Mari A.
10. Percorsi Avanzati in Allergologia – VIII Edizione - “La Diagnostica Allergologica del Terzo Millennio: il FABER Test in Nanotecnologia”. Pozzuoli (Na), Italy, 2016. Mari A.
11. SYMPOSIUM 4: Component Resolved Diagnostics (CRD): which role in clinical practice? - “Overview … on Allergenic Molecules in Allergy Diagnosis”. EAACI Food Allergy and Anaphylaxis Meeting – FAAM. Rome, Italy, 2016. Mari A.